Title: Mechanism of Gut Microbiota-Mediated Toxicity of Environmental Source Vibrio vulnificus and Prevention Strategies

Time: 15:00-17:00, November 21, 2025 (Friday)

Venue: Meeting Room 1408, Guanyun Building, Chengguan Campus, Lanzhou University

Reporter Profile:

Lin Huai, male, born in August 1990, is a postdoctoral fellow and assistant researcher at the School of Environment, Nanjing University. His research interests focus on environmental microbiology and health. He has published over 10 papers as the first author in journals such as Water Research, Chemical Engineering Journal, Journal of Hazardous Materials, and ISME Communications. He presides over the Young Scientists Fund Program of the National Natural Science Foundation of China (NSFC), the Guangdong Basic and Applied Basic Research Foundation (Young Scholars), and a sub-project of the National Key R&D Program. He has applied for one patent and participated in the compilation of two group standards. He has received awards including the First Prize of the Environmental Protection Technology Award from the Jiangsu Society Environmental Sciences (ranking sixth) and the National Scholarship.

Report Abstract:

Vibrio, a genus of curved Gram-negative bacteria, is widely distributed in estuaries, bays, coastal waters, and aquatic animals. Pollution incidents caused by Vibrio occur frequently worldwide. As a typical environmental source Vibrio, Vibrio vulnificus has an extremely high mortality rate, yet its mechanisms of toxicity remain unclear. The gut microbiota, the microbial community residing in the intestine, plays a significant role in host digestion and absorption, immune regulation, nutrient metabolism, and disease progression. Notably, approximately 80% of patients with Vibrio vulnificus infections have comorbid liver diseases. Given the structural and functional connection between the gut and the liver, the gut microbiota may participate in the infection process of Vibrio vulnificus.

From the perspective of microbial ecology, this report utilizes high-throughput sequencing and biological analysis techniques, combined with pathological, physiological, immunological, and metabolic assessments. It systematically elucidates the role and mechanism of the gut microbiota in Vibrio vulnificus infection and proposes targeted prevention strategies for specific populations, providing a theoretical basis and reference for the prevention and control of Vibrio vulnificus infections.

School of Earth and Environmental Sciences, Lanzhou University

November 26, 2025